| Lyme diseaseBorrelia bacteria | Blacklegged, western blacklegged | 3–30 days | Expanding "bull's-eye" or solid red rash (about 70–80% of cases), fever, chills, fatigue, joint aches. Untreated: arthritis, facial palsy, heart rhythm problems, nerve pain | Serious if untreated |
| Anaplasmosis | Blacklegged | 5–14 days | Fever, severe headache, chills, muscle aches; low blood counts on labs | Can be severe |
| BabesiosisParasite of red blood cells | Blacklegged | 1–4 weeks or longer | Fever, sweats, fatigue, dark urine from anemia. Dangerous for people without a spleen, older adults, the immunocompromised. Also spread by blood transfusion | Can be fatal |
| Powassan virus | Blacklegged, groundhog | 1 week–1 month | Fever, vomiting, confusion, seizures, brain inflammation. Can transmit in as little as 15 minutes. No specific treatment | About 1 in 10 severe cases fatal |
| Ehrlichiosis | Lone star | 1–2 weeks | Fever, headache, muscle pain, confusion; rash more common in children | Can be fatal |
| Rocky Mountain spotted fever | Dog tick, wood tick, brown dog tick | 3–12 days | Fever and headache first, then a spotted rash on wrists and ankles around day 2–4. Treat within 5 days of symptoms | Most deadly U.S. tick disease |
| Alpha-gal syndrome | Lone star (mainly) | Reaction 2–6 hours after eating | Hives, stomach pain, swelling or anaphylaxis after red meat, dairy or gelatin. CDC estimates up to 450,000 Americans affected | Can be lifelong |
| Tularemia | Dog tick, wood tick, lone star | 3–5 days | Skin ulcer at the bite, swollen lymph nodes, high fever | Treatable |
| STARI | Lone star | About 7 days | Lyme-like circular rash, fatigue, fever | Usually mild |
| Borrelia miyamotoi | Blacklegged | 1–2 weeks | High fever that can come back; rash uncommon | Treatable |
| Rickettsia parkeri | Gulf Coast | 2–10 days | Dark scab (eschar) at the bite, fever, rash | Treatable |
| Heartland & Bourbon viruses | Lone star | About 2 weeks | Fever, fatigue, low platelets and white cells. Rare; no specific treatment | Can be severe |
| Colorado tick fever | Rocky Mountain wood tick | 1–14 days | Fever that breaks and returns, headache, body aches | Usually recovers |
| Tick-borne relapsing fever | Soft ticks | About 7 days | Repeated 3-day fevers separated by about a week | Treatable |
| Tick paralysis | Dog tick, wood tick | After 4–7 days attached | Weakness spreading up from the legs. A toxin in tick saliva, not an infection: it reverses once the tick is found and removed | Find the tick |